منابع مشابه
Antimalaria Drug Development & Pipeline
Artemisin traditionally cleave the peroxide bond by Fe(II) found in heme proteins, thus generating toxic oxygen radicals. Synthetic peroxides, thus are proving to be useful substitutes for artemisinin. The first-generation ozonide OZ277, known as arterolane [1], has been found to inhibit the growth of chloroquine-resistant (K1) and chloroquine sensitive (NF54) parasite strains. In 2012, the com...
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Sir—The multicenter randomized trial reported by Overbosch and colleagues [1] is important for 2 reasons. First, the study shows that when taken as malaria prophylaxis, mefloquine is not well tolerated by many travelers. Of the study participants randomized to receive mefloquine, 67.1% reported 1 adverse event, and, in 6% of mefloquine users, these events were severe (defined as requiring medic...
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Malaria is a major infectious disease. In the last 10 years it has killed more than 20 million people, mainly small children in Africa. The highly efficacious artemisinine combination therapy is being launched globally, constituting the main hope for fighting the disease. Amodiaquine is a main partner in these combinations. Amodiaquine is almost entirely metabolized by the polymorphic cytochrom...
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Q uinacrine, an old antimalaria drug given to millions of soldiers during World War II, is garnering new interest as a chemotherapeutic agent that targets two major cancer-promoting pathways — apparently with minimal toxicity to normal cells.Interest in the drug’s mechanism of action has also spawned a search for structural analogues culminating in a new class of compounds, dubbed curaxins, whi...
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This article engages with debates about the conceptualisation and practical challenges of patient and public involvement (PPI) in health and social care services. Policy in this area in England has shifted numerous times but increasingly a consumerist discourse seems to override more democratic ideas concerning the relationship between citizens and public services. Recent policy change in Engla...
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ژورنال
عنوان ژورنال: BMJ
سال: 1919
ISSN: 0959-8138,1468-5833
DOI: 10.1136/bmj.1.3048.669